Processing and Use of Radiation Sterilized Human Amniotic Membrane Allografts as Biological Dressings of Wounds in Children: A Review

Radiation sterilized human amniotic membrane allografts are used as biological dressing of wounds in rehabilitative surgery. The is many different clinical situations such as: heat burn, chemical burns, diabetic wound/ foot ulcer, leprotic abdominal wall reconstruction, pterigium removal site, peripheral corneal the management pressure sore, etc.Non-viable lyophilized/oven-dried radiation could be processed for utilization temporary wounds. clinically should not carriers germs or a source infection. Human chorio-amniotic membranes collected processing tissue to dressings were reported contaminated with microorganisms species Staphylococcus, Micrococcus, Bacillus and Pseudomonas.However, oven dried (40ºC) freeze (-50ºC) found by irradiation dose 25 kiloGray (kGy) gamma radiation.Careful screening selection donors, proper sterilization minimize risk disease transmission recipients through allografts.
 DS (Child) H J 2021; 38(1): 49-55